MIND

Steven Hersch, MD, PhD

In recent years, Dr. Hersch has worked on understanding the role of huntingtin protein in the pathogenesis of HD utilizing human brain tissue and transgenic mouse models. At the same time, he has performed clinical research on Huntington’s disease, including clinical trials. Dr Hersch provides expertise in human and transgenic mouse neuropathology and therapeutics discovery using transgenic mouse models, and heads up all testing of potential therapeutic compounds on transgenic mouse models of HD. Three compounds are currently being tested and up to ten are slated for the next year. Steve is also in charge of clinical care provided by the MGH HD Center of Excellence, and is developing a translational program to rapidly bring research findings into the clinic. He also sees patients in the Movement Disorders unit at MGH.