MassGeneral Institute for Neurodegenerative Disease

Translating today's discoveries into tomorrow's cures

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Suh, Jaehong, PhD

Assistant Professor of Neurology, Harvard Medical School
Assistant Neuroscientist, Massachusetts General Hospital

Office Phone: 617-643-6899
Fax: 617-724-1823
Lab Address: CNY114, 3rd floor
Email: suh.jaehong@mgh.harvard.edu

Biography
Affiliations

Dr. Jaehong Suh studies the genetic and molecular mechanisms of Alzheimer’s disease (AD) and other neurodegenerative disorders, with the aim of identifying novel therapeutic targets and developing effective treatments for patients. Suh was involved in the identification of novel mutations from late-onset AD families in the prodomain of ADAM10, a major a-secretase that cleaves B-amyloid (AB region of amyloid precursor protein (APP).  Subsequently, Suh and his colleagues generated a mouse model with the same mutations and showed that the ADAM10 mutations attenuate a-secretase activity of the enzyme, potentiate the accumulation of AB and decrease the generation of new neurons in the brain. Suh and his lab continue to characterize additional ADAM10 mutations, and identify novel ADAM10 substrates in the brain. Additionally, Suh is pursing mechanistic studies on another AD-associated gene, Ataxin-1, which was found recently in a genetic screen of AD families. Expansion of CAG trinucleotide repeat in Ataxin-1 gene is known to cause spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease that primarily impairs coordinated movement.  Suh and his lab are investigating how loss of Ataxin-1 function affects the etiology and pathogenesis of AD. At MGH, Suh has also studied the role of FE56 and FE65L1 APP-binding proteins on APP processing in neurons and identified abnormal eye and muscle phenotypes in the knockout mice for the two genes. 

Biography 

Jaehong Suh received both his Bachelor and PhD degrees in Biological Sciences from the Korea Advanced Institute of Science and Technology (KAIST). His PhD research explored the molecular basis of adverse effects of dioxin and related compounds on immune function. He did postdoctoral training on neuronal cell death mechanism and tau splicing at Ajou University School of Medicine in Korea, and completed his training at MGH, where he studied genetics and neurobiology of AD with Dr. Rudolph Tanzi in the Genetics and Aging Research Unit. For that work, Suh received an Alzheimer’s Disease Research Fellowship from the BrightFocus Foundation. In 2014, he became an Assistant Professor of Neurology at Harvard Medical School and Assistant Neuroscientist at Massachusetts General Hospital.