MassGeneral Institute for Neurodegenerative Disease

Translating today's discoveries into tomorrow's cures

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DiFiglia, Marian, PhD

Biography
Affiliations

Marian DiFiglia is a Professor of Neurology at Harvard Medical School and Director of the Laboratory of Cellular Neurobiology at MassGeneral Institute for Neurodegenerative Disease. Sheleads a multidisciplinary research team investigating the role of the Huntington’s disease mutation in the molecular and cellular events leading to neurodegeneration in Huntington’s disease (HD).

Schwarzschild, Michael, MD, PhD

Biography
Affiliations

Michael Schwarzschild's lab investigates molecular mechanisms in mouse models of Parkinson’s disease in an effort to develop improved therapies for neurodegenerative diseases. His research extends to the clinic where he conducts trials of novel treatments with the potential to slow progression of Parkinson’s disease. The Schwarzschild lab focuses on a natural class of compounds known as purines, in particular the role of purines — adenosine, caffeine, inosine and urate — and how targeting them may prevent or slow the brain cell degeneration of Parkinson’s.

Hersch, Steven, MD, PhD

Biography
Affiliations

Steven Hersch’s research focuses on Huntington’s disease (HD) and helping to develop treatments to slow or cure this fatal progressive neurogenetic disorder. His laboratory works to discover and translate potential disease modifying therapies and biomarkers from the lab to the clinic.

Hyman, Brad, MD, PhD

Biography
Affiliations

Brad Hyman studies the anatomical and molecular basis of dementia in Alzheimer’s disease, and Dementia with Lewy Bodies. His research includes a collaborative of several labs working on different aspects of neurodegenerative disease and dementia. He also has a clinical practice in the Memory and Disorder Unit at the Massachusetts General Hospital devoted towards the care of patients with dementia.

Bacskai, Brian, PhD

Biography
Affiliations

Brian Bacskai uses optical techniques to ask fundamental questions in Alzheimer's disease research. Using the mulitphoton micrsocopy imaging technique, senile plaques of Alzheimer's disease can be detected and characterized in the brains of living transgenic mice. This approach was used to study a way to clear senile plaques based on immunotherapy, as well as to characterize new factors that target amyloid in preclinical development for PET imaging in humans.

Tanzi, Rudolph, PhD

Biography
Affiliations

Rudolph Tanzi is the Vice-Chair of Neurology (Research) at MGH and Director of the Genetics and Aging Research Unit at MIND. He is an elected "Professor Representative" to the MGH Executive Committee on Research and serves as the Chair of the Cure Alzheimer's Fund Research Consortium, for which he spearheads the Alzheimer’s Genome Project.

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