MassGeneral Institute for Neurodegenerative Disease

Translating today's discoveries into tomorrow's cures

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Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.

Knowledge-Base Development

We develop custom knowledge bases of diseases. Intense literature scanning is done by subject matter specialists and significant research hypothesis, claims and their evidence is curated in a semantic-web based platform for enhanced searches and interoperability with other knowledge repositories. All claims are linked to relevant proteins, organisms and cells for easy-to-use lookups.

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