MassGeneral Institute for Neurodegenerative Disease

Translating today's discoveries into tomorrow's cures

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Knowledge-Base Development

We develop custom knowledge bases of diseases. Intense literature scanning is done by subject matter specialists and significant research hypothesis, claims and their evidence is curated in a semantic-web based platform for enhanced searches and interoperability with other knowledge repositories. All claims are linked to relevant proteins, organisms and cells for easy-to-use lookups.

Bioinformatics Training

We provide hands-on bioinformatics training sessions to small groups of researchers. Topics include basic statistics, design of experiments, micro-array analysis, next-generation sequencing analysis, and use of common bioinformatics tools, etc.  Content and level will be tailored to the audience. Training room, equipment and materials will be provided.

Biomedical Data Management Solutions

We build biomedical data management solutions for complex genomics and drug discovery assay data. Researchers can share their experiments and data; annotate the biomaterials and assays with controlled vocabulary terms and perform initial data analysis. Enhanced search and browse capabilities are provided with the software. We leverage the eXFrame platform for this service, which was used to develop Stem Cell Commons.

Bioinformatics Analysis

Our group provides bioinformatics and statistical analyses. Sample analyses include in-silico target identification, database and literature searches, protein annotation, microarray analysis, and next-generation sequencing pipeline execution. Free consultation with an estimate of the work is provided to the researcher. Services include supervision by a senior bioinformatician and all required computing infrastructure.

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