MassGeneral Institute for Neurodegenerative Disease

Translating today's discoveries into tomorrow's cures

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Kim, Doo Yeon, PhD

Biography
Affiliations

Doo Yeon Kim studies pathogenic mechanisms of Alzheimer’s disease (AD) using both cellular and animal models. He and his team developed a three-dimensional (3D) human neural cell culture model of AD, which recapitulated key aspects of AD pathology including β-amyloid aggregation and β-amyloid-driven tau pathology. Dr. Kim’s lab also studies how Alzheimer’s beta-secretase, BACE1, regulates synaptic and axonal ion channel trafficking using cellular and mouse models.

Li, Airong, MD, PhD

Biography
Affiliations

Dr. Li applies molecular genetics techniques to identify and characterize genes associated with human disease. Dr. Li’s recent work includes investigation of the functional role of UBQLN1 in Alzheimer’s disease (AD) pathogenesis; identification and characterization of novel mutations in PSEN1 and PSEN2 in dilated cardiomyopathy patients; and determination of the effects of AD-associated presenilin and multiple diseases and traits-associated SOX5 on heart development and cardiac function. Dr. Li’s current research interests focus on genetic studies of AD and hidradenitis suppurativa.

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