MassGeneral Institute for Neurodegenerative Disease

Translating today's discoveries into tomorrow's cures

Facebook icon Twitter Icon

Arnold, Steven E., MD

Biography
Affiliations

Dr. Arnold leads a broad clinical and translational research program on Alzheimer’s disease and other neurocognitive disorders of aging. His major interests include clinicopathological correlation studies of molecular markers in human cerebrospinal fluid and postmortem brain tissue, the discovery and validation of biochemical biomarkers for diagnosis and staging of neurodegenerative dementias, and the design and conduct of novel, early phase and proof-of-concept clinical trials.

Lagier-Tourenne, Clotilde, MD, PhD

Biography
Affiliations

Clotilde Lagier-Tourenne performs patient-oriented research to understand the molecular mechanisms driving neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and to develop therapeutic strategies. Mutations and/or cellular mislocalization of several RNA binding proteins have been identified as central components in the pathogenesis of ALS and FTD. Using innovative cellular and genomics techniques, Lagier-Tourenne’s group explores the regulatory networks between RNA binding proteins and changes in RNA expression that occur in these diseases.

Moir, Robert, PhD

Biography
Affiliations

Robert Moir’s research focuses on the biochemical and cellular mechanisms of neurodegeneration in Alzheimer's disease (AD) and aging. His work has uncovered new therapeutic targets aimed at preventing the accumulation of beta-amyloid (Aβ), the primary neurotoxic agent in AD. Moir was the first to identify the low-density lipoprotein receptor protein (LRP) as the mediator of an important early step in Aβ production in the brain. Today, LRP-mediated Aβ clearance pathways are increasingly recognized as major targets for therapeutic intervention.

Zhang, Can (Martin), MD, PhD

Biography
Affiliations

Can (Martin) Zhang’s research is focused on identifying the mechanism of neurodegeneration in Alzheimer’s disease (AD), with the goal of identifying molecular targets and biomarkers that will translate into the development of novel therapeutic strategies for AD. The pathogenesis of AD is believed to be primarily driven by amyloid-B (AB), the principal component of senile plaques in the brain.

Sharma, Nutan, MD, PhD

Biography
Affiliations

Nutan Sharma combines clinical expertise in movement disorders with research into the genetics and pathophysiology of dystonia. As founder and director of the dystonia clinic at MGH, Dr. Sharma conducts systematic clinical evaluation of patients in a longitudinal study of the natural history of dystonia. She collaborates with MIND geneticists to identify new dystonia-causing genes, by collecting families with dystonia for careful clinical characterization and DNA analysis. To facilitate laboratory studies of dystonia mechanisms, Dr.

Ozelius, Laurie, PhD

Biography
Affiliations

Laurie Ozelius works to uncover genetic causes for movement disorders, especially dystonias and Parkinson’s disease. Dystonias are characterized by involuntary muscle contractions that lead to slow movements or abnormal postures. Dystonias can be localized, as in writers’ cramp or torticollis, or generalized, and they often run in families.

Chen, Xiqun, MD, PhD

Biography
Affiliations

Trained in clinical and basic neuroscience, Xiqun Chen studies the molecular biology of neurodegeneration in Parkinson’s disease (PD) and related disorders. Working with collaborators at MGH, the Harvard School of Public Health, and overseas, Chen’s group is pursuing the biological basis of the epidemiological link between PD and melanoma.  Studies have shown that Parkinson’s patients have a higher incidence of melanoma, and that melanoma patients have a higher risk of developing PD.

Suh, Jaehong, PhD

Biography
Affiliations

Dr. Jaehong Suh studies the genetic and molecular mechanisms of Alzheimer’s disease (AD) and other neurodegenerative disorders, with the aim of identifying novel therapeutic targets and developing effective treatments for patients. Suh was involved in the identification of novel mutations from late-onset AD families in the prodomain of ADAM10, a major a-secretase that cleaves B-amyloid (AB region of amyloid precursor protein (APP).

Pages